pantoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Treatment of anemia due to iron deficiency. Minor (1)gymnema decreases levels of iron sucrose by inhibition of GI absorption. Applies only to oral form of both agents. Although the original formula requires the weight in kilograms, values input in lbs are transformed. The usual total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. (See also Notes section. (2010) Diagnosis and management of iron deficiency anaemia: a clinical update. iron sucrose decreases levels of eltrombopag by inhibition of GI absorption. There is in depth information below the form on the method used and on the result provided. vitamin E decreases levels of iron sucrose by increasing hepatic clearance. Ferric gluconate: 12.5 mg/mL Schrier SL, Mentzer WC, Landaw SA. iron sucrose decreases levels of doxycycline by inhibition of GI absorption. Allow at least 30 minutes between administration of Feraheme and administration of other medications that could potentially cause serious hypersensitivity reactions and/or hypotension, such as chemotherapeutic agents or monoclonal antibodies. On the other hand, slow decreases, such as that in chronic occult gastrointestinal bleeding are often difficult to diagnose. Use Caution/Monitor. The primary endpoint was the proportion of patients with . Minor/Significance Unknown. Many patients with kidney disease cannot get enough iron from food and require injections. Keep all medical and lab appointments. A patients lean body weight (or actual body weight if less than lean body weight) should be utilized when determining dosage. Iron sucrose: 20 mg/mL. Do not dilute to concentrations below 1 mg/mL [see How Supplied/Storage and Handling [16.2].) The elemental iron product used is Iron sucrose 20 mg/mL. Ganzoni AM. Official Journal of the International Society of Nephrology. 1970;100(7):301303. Use Caution/Monitor. Minor/Significance Unknown.iron sucrose increases levels of calcium acetate by enhancing GI absorption. Treatment of iron deficiency anemia in adults - UpToDate Clinical calculators for obstetrics and gynaecology - calculosaurus gymnema decreases levels of iron sucrose by inhibition of GI absorption. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. These adverse reactions have occurred up to 30 minutes after the administration of Venofer injection. 2010;18(3). Aranesp (darbepoetin alfa) | Dosing Considerations Venofer treatment may be repeated if iron deficiency reoccurs. * Calculators are available in UpToDate to determine ideal body weight and lean body weight. PDF Protocol for the use of Intravenous Iron Dextran (CosmoFer Do not administer Venofer to patients with evidence of iron overload. March 2, 2015 [IRON SUCROSE REQUIREMENT CALCULATION FOR SEVERE ANEMIA] DPMU Anantapuramu | National Health Mission 1 Formula for calculating the required dose of Iron sucrose 2.4 X Pre-pregnancy Weight in Kgs X Hb% deficit{11-actual Hb%} in mgs Plus Iron required to replenish the iron stores = 500mg Prepregnancy Weight = 45 kgs . A patients lean body weight (or actual body weight if less than lean body weight) should be utilized when determining dosage. You may report side effects to Health Canada at 1-866-234-2345. Use alternatives if available. Access your plan list on any device mobile or desktop. Ferric gluconate: 12.5 mg/mL. 2010;18(3). 1 Dosing for patients who weigh less than 50 kg All Rights Reserved. Applies only to oral form of both agents. Oral iron therapy is the first method while IV therapy comes in place when there are contraindications or the body doesnt respond to the oral one. Applies only to oral form of both agents. Am J Hosp Pharm. Monitor Closely (1)iron sucrose decreases levels of penicillamine by inhibition of GI absorption. Applies only to oral form of both agents. Applies only to oral form of both agents. Your dosage and length of treatment are based on your medical condition, age, and response to treatment. Iron Sucrose (Ferogen): Indications, Dosage, Administration - Medcrine Use Caution/Monitor. Deferoxamine chelates iron. Recommended dosing and infusion rates for PI. Pediatric Patients: The most common adverse reactions (2%) are headache, respiratory tract viral infection, peritonitis, vomiting, pyrexia, dizziness, cough, nausea, arteriovenous fistula thrombosis, hypotension and hypertension. This product may contain inactive ingredients, which can cause allergic reactions or other problems. calcium chloride decreases levels of iron sucrose by inhibition of GI absorption. sodium citrate/citric acid will decrease the level or effect of iron sucrose by increasing gastric pH. PDF Injectafer (ferric carboxymaltose injection) - Food and Drug Administration Either increases effects of the other by pharmacodynamic synergism. Iron deficiency anemia calculator (diagnosis), Iron deficiency anemia vs. Venofer has not been studied in patients younger than 2 years old. Use Caution/Monitor. Slowing the infusion rate may alleviate symptoms. Applies only to oral form of both agents. For males: LBW = 50 kg + 2.3 kg for each inch of patients height over 5 feet For females: LBW = 45.5 kg + 2.3 kg for each inch of patients height over 5 feet Administration: I. provider for the most current information. Use Caution/Monitor. Minor/Significance Unknown. calcium citrate decreases levels of iron sucrose by inhibition of GI absorption. Kumpf VJ, Holland EG. Medicinal forms Avoid or Use Alternate Drug. Drug Dosing in Obesity Reference Table - ClinCalc.com Echocardiogram Z Score (NEW)(BETA TESTING) Edinburgh Postnatal Depression Scale. Symptoms associated with Venofer total dosage or infusing too rapidly included hypotension, dyspnea, headache, vomiting, nausea, dizziness, joint aches, paresthesia, abdominal and muscle pain, edema and cardiovascular collapse. Minor/Significance Unknown. Hemodialysis-dependent: 0.5 mg/kg IV q2weeks for 12 weeks; not to exceed 100 mg/dose, Non-dialysis dependent or peritoneal-dependent (on erythropoietin): 0.5 mg/kg IV q4weeks for 12 weeks; not to exceed 100 mg/dose, sodium sulfate/?magnesium sulfate/potassium chloride, sodium sulfate/potassium sulfate/magnesium sulfate, Serious hypersensitivity reactions reported, including anaphylactic-type reactions, some of which have been life-threatening and fatal, Patients may present with shock, clinically significant hypotension, loss of consciousness, and/or collapse, If hypersensitivity reactions or signs of intolerance occur during administration, stop infusion immediately, Monitor patients for signs and symptoms of hypersensitivity during and after administration for at least 30 minutes and until clinically stable following completion of the infusion, Animal reproduction studies of iron sucrose administered to rats and rabbits during period of organogenesis at elemental iron doses equivalent to maximum recommended human dose based on body surface area revealed no evidence of harm to the fetus; adverse outcomes in pregnancy occur regardless of health of mother or use of medications, Iron deficiency anemia during pregnancy should be treated; untreated IDA in pregnancy is associated with adverse maternal outcomes such as post-partum anemia; adverse pregnancy outcomes associated with IDA include increased risk for preterm delivery and low birth weight, HD-dependent and non-dialysis-dependent CKD: Dilute with up to 100 mL of 0.9% NaCl, PD-dependent CKD: Dilute with up to 250 mL of 0.9% NaCl, Undiluted: Administer by slow IV injection over 2-5 min, Diluted solutions: Administer IV over 15 min, Undiluted: Administer by slow IV injection over 5 minutes, Diluted solutions: Administer IV over 5-60 minutes, Store in original carton at 20-25C (68-77 F); excursions permitted to 15- 30C (59-86F), Syringe: Store at room temperature (25C) or under refrigeration (4C) for up to 7 days, IV infusion: Store at room temperature (25C) for up to 7 days. This medicine is sometimes given slowly, and the infusion can take up to 2.5 hours to complete. Dosage: For patients weighing 50 kg (110 lb) or more: Give Injectafer in two doses separated by at least 7 days. Information last revised December 2022. Applies only to oral form of both agents. May increase risk of hypotension. Use Caution/Monitor. The dosage of Venofer is expressed in mg of elemental iron. Patients measured hemoglobin can be input in g/dL or mmol/L. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every two weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. May increase risk of hypotension. FERAHEME met the predefined criteria for non-inferiority to Venofer . Applies only to oral form of both agents. When administered via infusion, dilute up to 750 mg of iron in no more than 250 mL of sterile 0.9% sodium chloride injection, USP, such that the concentration of the infusion is not less than 2 mg of iron per mL and administer over at least 15 minutes. Iron sucrose can also be mixed in a saline solution and given through an IV over a longer time. If dose exceeds 20mg/kg it should be rounded down to 20mg/kg OR administration of the total dose has to be split and given 7 days apart. Dosing and Infusion Rates - PRIVIGEN WARNING: RISK FOR SERIOUS HYPERSENSITIVITY/ANAPHYLAXIS REACTIONS Fatal and serious hypersensitivity reactions including anaphylaxis have occurred in patients receiving Feraheme. Hanson DB, Hendeles L. Guide to total dose intravenous iron dextran therapy. Although anaphylactic reactions known to occur following INFeD administration are usually evident within a few minutes, or sooner, it is recommended that a period of an hour or longer elapse before the remainder of the initial therapeutic dose is given. Most Applies only to oral form of both agents. Serious - Use Alternative (1)iron sucrose decreases levels of fleroxacin by inhibition of GI absorption. Interaction only with oral iron administration. For liquid medications, also enter the value of the Medicine Concentration and choose . Applies only to oral form of both agents. Applies only to oral form of both agents. Applies only to oral form of both agents. Where C= concentration of Use Caution/Monitor. HONcode standard for trust- worthy health, Pediatric Oncology: Diagnosis And Prognosis Communication. The original formula employs the weight in kg but users can input it in lbs and it gets transformed. DICP. feasible, Maximum total cumulative iron sucrose dose administered in 14 days is 1000 mg elemental iron. DailyMed - VENOFER- iron sucrose injection, solution The dosage of Venofer is expressed in mg of elemental iron. Administer Venofer in 3 divided doses, given by slow intravenous infusion, within a 28 day period: 2 infusions each of 300 mg over 1.5 hours 14 days apart followed by one 400 mg infusion over 2.5 hours 14 days later. Each mL contains 20 mg of elemental . Serum iron, total iron binding capacity (TIBC) and percent saturation of transferrin are other important tests for detecting and monitoring the iron deficient state. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. PRECAUTIONS: Before using iron sucrose, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. Venofer (iron sucrose) dose calculator | Calculosaurus.com Minor/Significance Unknown. iron sucrose decreases levels of fleroxacin by inhibition of GI absorption. Monitor Closely (1)esomeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Serious - Use Alternative (1)iron sucrose decreases levels of minocycline by inhibition of GI absorption. Iron deficiency can occur at any stage of life, due to physiological demands, for example, during pregnancy, childhood growth or prolonged periods of sickness. World J Gastroenterol; 16(22): 27202725. A: Generally acceptable. Studies in monkeys showed concurrent use with calcium, aluminum, or iron caused significantly decreased plasma levels. Applies only to oral form of both agents. Written by ASHP. Oral and parenteral products - see background option for oral products. Venofer (iron sucrose injection, USP) is a brown, sterile, aqueous, complex of polynuclear iron (III)- . Applies only to oral form of both agents. OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. 5. Adult Patients: The most common adverse reactions (2%) include diarrhea, nausea, vomiting, headache, dizziness, hypotension, pruritus, pain in extremity, arthralgia, back pain, muscle cramp, injection site reactions, chest pain and peripheral edema. DOSAGE AND ADMINISTRATION: Venofer must only be administered intravenously either by slow injection or by infusion. UpToDate. Dose. Use Caution/Monitor. Applies only to oral form of both agents. IDA diagnosis is based on full blood examination and on the serum ferritin level. 2010niferex-hytinic-polysaccharide-iron-342160Drugs, You are being redirected to Then you can click on the Print button to open a PDF in a separate window with the inputs and results. Applies only to oral form of both agents. Applies only to oral form of both agents. Calculates iron deficit for dosing iron. Anemia of chronic disease (ACD), Calculation of the Total Iron Deficit equation appears in Cosmofer PI, Iron Dextran Dosing Calculator (iron deficit). Monitor Closely (1)iron sucrose decreases levels of thyroid desiccated by inhibition of GI absorption. In this study and another study evaluating a single intravenous dose of iron sucrose containing 500-700 mg of iron in 26 anemic patients on erythropoietin therapy (23 female, 3 male; age range 16-60), approximately 5% of the iron was . Feraheme does not contain antimicrobial preservatives. This website also contains material copyrighted by 3rd parties. Normal haemoglobin values are gender specific: for males from 13.8 to 18.0 g/dL (138 to 180 g/L, or 8.56 to 11.17mmol/L) and females from 12.1 to 15.1 g/dL (121 to 151 g/L, or 7.51 to 9.37mmol/L). Feraheme, when added to intravenous infusion bags containing either 0.9% Sodium Chloride Injection, USP (normal saline), or 5% Dextrose Injection, USP, at concentrations of 2-8 mg elemental iron per mL, should be used immediately but may be stored at controlled room temperature (25C 2C) for up to 4 hours or refrigerated (2-8 C) for up to 48 hours. iron sucrose decreases levels of penicillamine by inhibition of GI absorption. There are three fields in the parenteral iron replacement for iron deficiency anemia calculator: Weight can be input in either lbs or kilograms and the required transformations are performed by the calculator. You may need extra iron because of blood loss during kidney dialysis. Applies only to oral form of both agents. Calculation of total iron deficit for initial repletion: [29] Total cumulative dose (mg) = [Target Hb Actual Hb] weight (kg) 2.4 + [15 weight (kg)] *Hb in g/dl: 2. The therapeutic management of IDA focuses on the replenishment of the iron stores through methods that have been mentioned above. Max Dose. The dosing for iron replacement treatment in pediatric patients with NDD-CKD or PDD-CKD has not been established. Jacobs P, Dommisse J. There are physiological variation in iron reserves such as the decrease during menstruation period. We'll do this entirely for free, as long as the calculator has applications for women's health. Adult Patients with Non-Dialysis Dependent-Chronic Kidney Disease (NDD-CKD): Administer Venofer 200 mg undiluted as a slow intravenous injection over 2 to 5 minutes or as an infusion of 200 mg in a maximum of 100 mL of 0.9% NaCl x 15 minutes. Manage and view all your plans together even plans in different states. ibuprofen/famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Dr. Ganzonis primary research is focused on iron deficiency and plasma iron transport. Minor (2)calcium gluconate decreases levels of iron sucrose by inhibition of GI absorption. Applies only to oral form of both agents.
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