Data generated by these studies establish that Simparica Trio is thoroughly and rapidly effective, as well as safe, under both experimental and natural conditions, when given monthly at minimum labeled oral doses against the two arthropods for which it was designed. Eye/face protection If contact is likely, safety glasses with side shields are recommended. http://www.cdc.gov/ticks/geographic_distribution.html. For I. scapularis, D. variabilis, R. sanguineus and A. maculatum, a single dose of Simparica Trio showed nearly 99% efficacy 48 hours following initial treatment, and over 90% efficacy within 48 hours after all re-infestations through day 28; for one of the two strains of R. sanguineus, there was a slightly lower kill rate (89.7%) on day 14. Do I need a prescription for Simparica Trio? Simparica Trio kills fleas before they can even lay eggs. 2009; 4. Updated January 10, 2019. The dogs were treated with Simparica Trio at the approximate minimum labeled oral dose on day 0, and then infested with approximately 50 unfed adult ticks on days two, five, 12, 19, 26 and 33. Following weekly re-infestations, the drug reduced fleas by about 98% within 12 hours through day 28. You can begin using Simparica Trio with puppies as young as 8 weeks old weighing at least 2.8 lbs. How is Simparica Trio different from other preventatives? A total of 422 dogs from 251 households of three or fewer dogs (with at least one dog harboring 10+ fleas) were enrolled. Read more about the triple protection of Simparica Trio. Flea killing ramped up at four hours after treatment, and all treated dogs were flea-free at eight hours. It starts to kill deer ticks within 8 hours, and fleas within 4 hours. Interceptor® Plus [package insert]. When can I start Simparica Trio for a puppy? In a field safety and effectiveness study, SIMPARICA TRIO … and precautions for firefighters In … Accessed March 21, 2019. April 12, 2017. https://capcvet.org/guidelines/ticks. How is Simparica Trio different from other preventatives? Simparica Trio has been demonstrated safe for dogs as young as 8 weeks old, and weighing as little as 2.8 lbs. Centers for Disease Control and Prevention. In each study, 10 dogs were assigned randomly to one of two treatment groups based on prior host-suitability tick counts. Trifexis® [package insert], Greenfield, IN: Elanco; 2016. Simparica Trio works to get rid of ticks and fleas on dogs fast. McTier TL, Chubb N, Curtis MP, et al. Revised June 2019. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history … Safety and treatment This product kills the flea and tick, which mean you give pesticide to the dogs. If a dose is missed, a new dose should be given immediately. Geographic distribution of ticks that bite humans. For animal use only. *Bravecto®, NexGard®, and Credelio® are approved to kill only four types of ticks. Field efficacy and safety … Not limited to … If a dose is vomited or spit out, a new dose should be given again. Yes. How ticks spread disease. The animal health information contained herein is provided for educational purposes only and is not intended to replace discussions with an animal healthcare professional. Ozoe Y, Asahi M, Ozoe F, et al. Protect your dog with three proven ingredients designed for defense. What are the symptoms of heartworm disease in dogs? Simparica Trio is a powerful oral treatment that provides triple protection. Simparica Trio protects against ticks & fleas too. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea. Flea counts and examinations for flea allergy dermatitis (FAD) were performed immediately before the initial treatment and again at days 30 and 60. Simparica Trio reduced live flea counts, as well as clinical signs of FAD, by 99.0% at day 30 and by 99.7% at day 60. How often do you give Simparica Trio? Your browser has JavaScript disabled, please turn it on in your browser settings. Efficacy of a novel orally administered combination product containing sarolaner, moxidectin and pyrantel (Simparica Trioâ¢) against induced infestations of five common tick species infesting dogs in the USA. 2016;222:3-11. In a field safety and effectiveness study, SIMPARICA TRIO was administered to dogs for the prevention of heartworm disease. Biology, Treatment, and Control of Flea and Tick Infestations. The second study, which encompassed five trials,5 evaluated efficacy in a laboratory setting. A single oral administration of Simparica Trio™ chewable tablets was well tolerated and was effective in the treatment of dogs with naturally occurring gastrointestinal nematode infections presented as veterinary patients in Europe and the USA.